[Formal representation and reasoning for microscopic medical image-based prognosis] ( [application to breast cancer grading].)

Cette thèse aborde l'aide du pronostic basée sur l'image et les ontologies médicales, en utilisant la représentation des connaissances et le raisonnement pour les très grandes images microscopiques. Une application médicale particulière dans laquelle une assistance de type pronostic est nécessaire est la graduation du cancer du sein. Même si cela est considéré comme un outil d'évaluation essentiel dans la pratique de pathologie moderne les principaux problèmes posés par la procédure manuelle de pronostic sont: la nécessité des connaissances, attention et temps. D'autre part, le manque de reprédentation sémantique formelle standardisée pour aider l'indexation et la classification de la terminologie, ainsi que l'utilisation d'un mécanisme d'inférence pour assister le graduation représentent des problématiques clé du domaine. Dans ce sens, cette étude propose une représentation formelle qualitative pour la graduation du cancer du sein ainsi qu'une ontologie d'application Brest cancer Grading Ontology (BCGO) pour décrire les connaissances d'une manière cohérente. Une autre question que nous adressons en proposant l'ontologie, est le fossé sémantique entre les concepts sémantiques de haut niveau et les caractéristiques de l'image de bas niveau. En plus, nous proposonsun soutien de théorie spatiale pour la représentation des relations spatiales entre les concepts spécifiques à la graduation du cancer du sein. L'ontologie BCGO est intégré dans une plateforme microscopique cognitive virtuelle MICO, pour l'exploitation visuelle, l'indexation et l'extration sémantique des l'images microscopiques.This thesis addresses ontology-driven prognosis assistance using knowledge representation and reasoning for very large microscopic medical images. One particular medical application in which prognosis assistance is needed is the breast cancer grading. Althrough this is considered the key assessment tool in prognosis of modern pathology pratice, the main problems of the manual procedure are: time constraint, the need of knowledge and attention. More over, the lack of formal standardized semantic representation for the indexing and classification of terminology and the lack of an inference mechanism to assist the grading are key issues of the domain. To this end, we propose a qualitativ ontological representation of breast cancer grading, an application ontology entlited Breast Cancer Grading Ontology (BCGO) based on OWL-DL and SWRL formalisms. Using this approach, the thesis also tackles the semantic gap between the high-level semantic concepts and the low-level image features. Additionally, we propose a spatial theory support for the representation of the spatial relations between the spatial concepts of the breast cancer grading. This ontology is integrated into a cognitive microscope framework MICO, guiding the image exploration, semantic indexing and retrieval of the microscopic imagesBESANCON-BU Sciences Staps (250562103) / SudocSudocFranceF

Logical Analysis on the Strategy for a Sustainable Transition of the World to Green Energy—2050. Smart Cities and Villages Coupled to Renewable Energy Sources with Low Carbon Footprint

This paper brings, as an element of novelty and originality, a strategic feasibility study, in the form of a logical analysis related to the proposed objective, with particularization to the area of the EFTA plus the UK and Ireland. We tried to achieve an overall picture of a sustainable and prudent transition at the macroeconomic level, but also at the microeconomic and local levels, with specific values of ecological and energy-smart villages/towns. The convergent actions of the signatory states of the climate treaty COP-26/2021—Glasgow, UK are to improve the logistics and financing of the large-scale replacement of fossil fuels used in the economy and lives of human society. Various strategies have been discussed to address the energy mixes that could be used in the transition phase in stages and combined-cycle natural-gas plants, conditioned by the implementation of CCUS technology. The preliminary stage will focus on the provision and implementation of modern technologies for the production of electricity in photovoltaic and wind power. Starting with the 2030s, the industrialized production of blue and green hydrogen is expected; the first is expected to be obtained from the chemical synthesis of natural gas with the separation and storage of residual carbon from chemical reactions, and the second directly from ocean water through the phenomenon of H2O electrolysis. As a basic legislative element, the strategy aims to refine the idea of a carbon tax at the border or at the user, in order to discourage the use of fossil fuels

Logical Analysis on the Strategy for a Sustainable Transition of the World to Green Energy—2050. Smart Cities and Villages Coupled to Renewable Energy Sources with Low Carbon Footprint

This paper brings, as an element of novelty and originality, a strategic feasibility study, in the form of a logical analysis related to the proposed objective, with particularization to the area of the EFTA plus the UK and Ireland. We tried to achieve an overall picture of a sustainable and prudent transition at the macroeconomic level, but also at the microeconomic and local levels, with specific values of ecological and energy-smart villages/towns. The convergent actions of the signatory states of the climate treaty COP-26/2021—Glasgow, UK are to improve the logistics and financing of the large-scale replacement of fossil fuels used in the economy and lives of human society. Various strategies have been discussed to address the energy mixes that could be used in the transition phase in stages and combined-cycle natural-gas plants, conditioned by the implementation of CCUS technology. The preliminary stage will focus on the provision and implementation of modern technologies for the production of electricity in photovoltaic and wind power. Starting with the 2030s, the industrialized production of blue and green hydrogen is expected; the first is expected to be obtained from the chemical synthesis of natural gas with the separation and storage of residual carbon from chemical reactions, and the second directly from ocean water through the phenomenon of H2O electrolysis. As a basic legislative element, the strategy aims to refine the idea of a carbon tax at the border or at the user, in order to discourage the use of fossil fuels